| Article 38 Published on August 6, 2016 |
The Treatment Of Bone Diseases And Diabetes With SR10171 Compound
The risk of bone fracture is two-fold in patients with diabetes. Some antidiabetic drugs also increase the risk of bone fracture in diabetes patients.
A proper balance between bone formation (new bone development) and bone turnover (replacing old bone) is missing in patients with diabetes. A new compound, referenced as "SR10171", was developed at the Scripps Research Institute (TSRI) and the new drug can be used for the treatment of bone disease and diabetes.
The new drug shows an increase in the bone mass by bone formation and bone turnover, irrespective of BMI and diabetes status, in both normal or obese people.
The authors of the study are Prof. Patrick R. Griffin (The Scripps Research Institute, TSRI) and Prof. B Lecka-Czernik (University of Toledo). The study was published in the Journal EBioMedicine.
A Study On EGFR Trajectory
The Estimated Glomerular Filtration Rate (eGFR) is a test to detect the damage to the kidneys.
A study led by Dr. Timothy Davis, the University of Western Australia has analyzed the effects of eGFR on 1,296 people with type 2 diabetes (T2D).
The study shows that patients with type 2 diabetes should regularly monitor the Estimated Glomerular Filtration Rate (eGFR).
A rapid decline in the renal function with a high eGFR can increase the risk of death in patients with type 2 diabetes (T2D).
The study was published in the European Journal of Endocrinology.
The Risk With High Body Mass Index (BMI)
A study by Prof. Peter Nordstram, Sweden shows that the higher body mass index (BMI) can increase the risk of diabetes but there is no effect on the risk of heart attack.
Experts say a BMI between 18.5 and 24.9 is ideal. Between 25 and 29.9 is categorized as overweight and above 30 is categorized as obese.
The researchers have examined about 4,000 genetically identical twins derived from a single ovum to evaluate the risk associated with genetic factors and obesity.
The study shows that weight loss can lower the risk of diabetes. The health benefits of weight loss are more to diabetes when compared with cardiovascular disease (CVD) or mortality.
The study was published online in the JAMA Internal Medicine.
Diabetes Induced Cognitive Impairment
An earlier study has indicated that diabetes can increase the risk of age-related cognitive declines, such as memory and thinking skills.
Even the younger people with diabetes are showing the sign of cognitive decline. A person with mild cognitive impairment (MCI) is at a higher risk of Alzheimer's or dementia.
The Risk From Adrenal Tumors (NFATs)
A retrospective observational study by Dr. Anand Vaidya, MD, the Harvard Medical School, Boston has indicated a 2-fold increased risk of diabetes or prediabetes in patients with the non-functional adrenal tumors (NFATs).
The study shows that the non-functional adrenal tumors (NFATs) may secrete excess glucocorticoids, which may increase the risk of metabolic diseases and diabetes.
The study was published in the journal Annals Of Internal Medicine. The study was funded by the National Institutes of Health and the Doris Duke Charitable Foundation.
The Risk From Statin Pills
Statin pills are used to lower the bad cholesterol levels from the body to protect against heart disease.
A study by lead researcher Dr. Michael Holmes, from Oxford University shows that statin pills can decrease the bad cholesterol from our body but can increase the risk of diabetes.
The lower levels of low-density lipoprotein (LDL) cholesterol can cause a lower risk of heart diseases with the use of statin pills but increases the risk of type 2 diabetes (T2D).
To avoid diabetes, a patient using statin pills should increase the levels of high-density lipoprotein (LDL) cholesterol.
But the guidelines for both the diseases may not change as the benefits of statin pills are more. The study was published in the journal JAMA Cardiology.
The Risk Of Heart Attack And Diabetes Before Menopause
A study on about 1,500 women shows the increased risk to diabetes, heart disease and stroke before the onset of menopause in women. The risk is lower in postmenopausal women.
The researchers have analyzed the following five important factors (called metabolic syndrome) that may increase the risk of heart disease in women.
- High blood sugar levels.
- High blood fat.
- Low HDL or "good" cholesterol.
- Large waistline.
- High blood pressure (BP).
The researchers say that the above five factors (called metabolic syndrome) can increase the risk of diabetes and heart diseases. The study was published on Aug 3, 2016, in the Journal of the American Heart Association.
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