Diabetes, Heart and Cardiovascular Diseases News Chronicle.  Diabetes, Cardiovascular and Heart Diseases
 Article 113
    Published on January 17, 2017

 

Lower health risk with the sauna bath

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The Kuopio Ischaemic Heart Disease Risk Factor Study (KIHD) at the University of Eastern Finland shows that sauna bath for four to seven times in a week can lower the risk of Alzheimer's by 65 percent and the risk of dementia by 66 percent. Sauna bath can also lower the blood pressure. The lower blood pressure can increase the blood circulation to all organs and lower the risk of other diseases.



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In sauna bath, the room temperature varies between 160°F and 195°F. Stoves and rocks can be used to generate the heat. A person can get health benefits such as the muscle relaxation and the lower blood pressure levels with the sauna bath.


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Transforming the alpha cells into beta cells

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A study at the CeMM Research Center for Molecular Medicine, Austria shows a new way for the treatment of type 1 diabetes (T1D) by transforming the glucagon-producing alpha cells into the insulin-producing beta cells. There are five types of cells in the Pancreatic islets (also known as the islets of Langerhans) to regulate the blood sugar levels. They are.


  • About 15 to 20 percent of the islet cells are alpha cells. Alpha cells secrete the hormone called glucagon. The blood sugar levels increase when the glucagon (a hormone) stimulates the liver to convert the glycogen into glucose.
  • About 65 to 80 percent of the islet cells are Beta cells. Beta cells secrete the insulin and amylin hormone. The insulin hormone helps in lowering blood sugar levels. Amylin hormone helps in preventing the spike in blood sugar levels and slowing the gastric emptying.
  • About three to ten percent of the total islet cells are delta cells. Delta cells secrete the somatostatin hormone. Somatostatin hormone will stop the release of other hormones secreted in the pancreas.
  • About three to five percent of the islet cells are gamma cells. Gamma cells secrete the pancreatic polypeptide hormone. Polypeptide hormone will regulate both the endocrine and exocrine pancreatic secretions.
  • Less than one percent of the islet cells are epsilon cells. Epsilon cells secrete ghrelin, a hunger hormone.

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It was known from the previous study that the glucagon-secreting pancreatic alpha cells can turn into the insulin-secreting pancreatic beta cells with the help of epigenetic regulator known as aristaless related homeobox (Arx) gene. Artemisinins drugs are a group of drugs used for the treatment of malaria. These drugs can cause loss of aristaless related homeobox in the pancreas and transform and reshape the glucagon-secreting alpha cells into the insulin-secreting beta cells.

Trials on mice, zebrafish and rat models were successful. Researchers say a study has to be done to find out the long-term effect of artemisinins. Researchers need a way to protect the transformed cells from the immunity system for the treatment of type 1 diabetes (T1D). The lead author of the study is Stefan Kubicek and the study was published in the journal Cell.


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Glycogen : The liver release glycogen (a large molecule) from glucose and stores it in the liver, muscles and in the bloodstream. To maintain normal blood sugar levels, the liver has the capability to convert glucose into glycogen and glycogen into glucose. Carbohydrates are the main source for the creation of glycogen. The Liver release glycogen from the fat and protein but with a reduced efficiency.


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FDA approval of Jardiance drug

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The United States FDA has approved Jardiance oral drug, the first treatment of its kind, to lower the risk and death due to cardiovascular disease in the patients with type 2 diabetes (T2D). The trial with the Jardiance drug shows the drug can lower the risk of heart attack and stroke.

Jardiance oral tablet is manufactured by the Boehringer Ingelheim, Ingelheim, Germany. This treatment is for patients with type 2 diabetes (T2D). Jardiance oral drug will not work for patients with type 1 diabetes (T1D) and patients with diabetic ketoacidosis.



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