Diabetes, Heart and Cardiovascular Diseases News Chronicle.  Diabetes, Cardiovascular and Heart Diseases
 Article 33
    Published on July 28, 2016


Risk With Genetic Variations

A study done by British scientists says type 2 diabetes (T2D) might be inherited and better understanding the condition could lead to individual personalized treatments in the future. Over 300 medical fraternity across 22 countries compared to genetic variations in 120,000 individuals with and without diabetes and found that genetic variations are common and shared differences in gene codes. Each gene is adding small risk chance to diabetes and researchers believe that there must be unknown rare gene variants with significant risk to diabetes.



       
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Risks When TGF-beta Genes Fail To Respond

Even though physical exercise lowers risk to the development of diabetes, metabolic impact (changes in the muscles) of physical exercise fails in one in five cases. A team of researchers led by Prof Cora Weigert from German Center for Diabetic Research found that the muscles of the nonresponding individuals reveal that messenger substance "Transforming Growth Factor beta" (TGF-beta) was not activated during physical exercises. TGF-beta plays important role in tissue development. TGF-beta will be activated in the event of inflammations and injuries. TGF-beta participates in the regeneration process. TGF-beta is important in burning glucose and fat and reducing insulin sensitivity. Currently, researchers are studying what causes TGF-beta to activate. The study findings were published in the Diabetes journal.



       
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Study Of Cavefish Metabolism

A study conducted by Nicolas Rohner Ph.D from the Stowers Institute for Medical Research says even though cavefish have disease symptoms like diabetes and nonalcoholic fatty liver diseases (NAFLD) similar to humans, they remain healthy and don't face health problems. Researchers observed following conditions in cavefish which are similar to humans but no negative effects on cavefish health.

  • Liver contains high levels of fat, similar to humans
  • Blood glucose levels rise too high levels immediately after eating
  • Blood glucose levels fall to very low levels when not consuming food
  • Swing in blood glucose levels from very low to very high levels

Understanding how cavefish immune system and genes fight chronic diseases may help us in fighting similar diseases in humans.



       
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Risks With Metabolic Syndrome

A combination of obesity, diabetes and high blood pressure (BP) is called metabolic syndrome. Researchers led by Dr. Susan Trompeter from San Diego School of Medicine, University of California surveyed 376 postmenopausal women and found that older women with metabolic syndrome reported less sexual satisfaction and frequency and are at risk of heart disease, stroke and affects blood vessels.



       
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Risks With Gut Bacteria Imbalance

A study done by Prof Oluf Pedersen from the University of Copenhagen shows an increase in the insulin resistance in the body is due to imbalances in gut microbiota. Imbalances in gut microbiota induce other diseases like type 2 diabetes (T2D), hypertension and CVD etc. Researchers observed that insulin resistance is linked to rising in the levels of branched-chain amino acids (BCAAs, a subgroup of amino acids) in the blood. The rise in BCAAs is linked to changes in gut microbiota composition and how it functions. The bacteria in the gut linked to changes in BCAAs are prevotella copri and bacteroides vulgatus. Researchers tested in mice with prevotella copri bacteria and results show increased levels of BCAAs in blood, intolerance to glucose and insulin resistance.



       
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Warning Signs In Thin People

A study done by researchers from the University of Florida on healthy weight adults found that 20 percent of them are at the risk of developing diabetes and 33 percent of them with over 45 years of age are meeting prediabetes criteria. Prediabetes is the condition where blood sugar levels are high but not high enough to be diagnosed with diabetes. Dr. Arch Mainous III is the lead investigator of the study.



       
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