| Article 189 Published on May 16, 2017 |
Obesity Increases Type 2 Diabetes Or Post Donation Diabetes Mellitus (PDDM) Risk Among Living Kidney Donors (LKD)
A study shows higher risk of type 2 diabetes (T2D) among living kidney donors (LKD) who are overweight or obese. The researchers have studied the pre-donation pharmacy fill records of 20,138 living kidney donors (LKD). The researchers checked insulin and non-insulin based diabetes medicines used by the living kidney donors (LKD) individuals with pharmacy fill to find out new onset post-donation diabetes mellitus (PDDM).
The average age of living kidney donors (LKD) individuals is 42.7 years. 40.8 percent of the individuals were overweight (body mass index BMI between 25 and 30 kg/m2 ) and 22.8 percent of the individuals are obese (body mass index BMI more than 30 kg/m2 ). Medications to treat post-donation diabetes mellitus (PDDM) in living kidney donors (LKD) increased gradually. The study findings show
- A five-year risk of post-donation diabetes mellitus (PDDM) medication treatments other than insulin increased in a graded manner as BMI increases. It is 0.6 percent in normal weight LKD individuals, 1.5 percent in overweight LKD individuals and 3.4 percent in obese LKD individuals
- A five-year risk of diabetes was found to be 3.0 fold higher in overweight LKD individuals and 6.4 fold in obese LKD individuals compared with normal weight LKD individuals
- Adjusted five-year risk of insulin usage was five-fold higher in obese LKD individuals compared with normal weight LKD individuals
The above study findings show obesity is a risk factor for post-donation diabetes mellitus (PDDM) in living kidney donors (LKD) individuals. Author of the study is Professor Krista L Lentine, MD, PhD, at Saint Louis University (SLU), Saint Louis, Missouri and the study findings were presented at the 2017 American Transplant Congress, Chicago.
A German Study Shows Zinc Supply Affects Heart Health
A study at Technical University, Munich shows an increased risk of cardiovascular diseases and cardiac function due to oxidative stresses associated with low levels of zinc in the body. An earlier study has indicated an increased cellular stress with very low levels of zinc. But the probolity of very low levels of zinc is very rare.
The researchers have monitored the vitamin E and glutathione antioxidants in the young piglets. The free radicals were disabled by vitamin E and glutathione antioxidants.
The researchers have conducted the experiment by varying nutritional zinc level in the piglets for few days to find out how the heart muscles are affected by declining amount of zinc.
The study shows as the zinc level in the body decline, levels of vitamin E and glutathione in the heart muscle too declined.
The reduction in vitamin E and glutathione level has affected the ability of the heart in handling oxidative stress.
The lead author of the study is Daniel Brugger, the Technical University, Munich. The study was published in the journal Nutrition. Title of the article is "Short-Term Subclinical Zinc Deficiency in Weaned Piglets Affects Cardiac Redox Metabolism and Zinc Concentration."
Zinc : Zinc is a natural metal and our body require a small amount of this metal for a multiple number of body functions and to activate body enzymes.
The following are the important functions of zinc in our body.
- Healthy cell division.
- The prevention of free radicals.
- Learning and memory function.
- Healing of wounds or ulcers.
- Improvement in the immunity.
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