Diabetes, Heart and Cardiovascular Diseases News Chronicle.  Diabetes, Cardiovascular and Heart Diseases
 Article 201
    Published on June 6, 2017

Statins Reduce Risk of Heart Attack And Stroke Even in People With Intermediate-Risk

A study done by researchers at the McMaster University Hamilton, Ontario, Canada shows risk reduction to stroke and heart attack in individuals with cholesterol-lowering statins drugs, even if the risk is moderate. Further risk reduction was observed when the patients took blood pressure (BP) lowering drugs along with statins among those patients having high blood pressure (BP) and they are at higher risk of stroke and heart attack.

HOPE-3 study (Heart Outcomes Prevention Evaluation-3) shows dual low-dose therapy is the best way to reduce cardiovascular events risk among older individuals who are with hypertension or high blood pressure (BP) and with just normal cholesterol levels but having another risk factor such as obesity or smoking. HOPE-3 study findings recommend statins usage in more people and support guidelines of the heart association and the American College of Cardiology. The study shows statins are safe and effective in reducing heart attack and strokes in individuals aged over 55 years with intermediate risk factors.

Researchers studied 12,705 individuals aged over 55 years with 6 years follow up studies. All of them are taking some type of medications such as statins, placebos, blood pressure controlling medications and some are taking both statins and blood pressure medications. The study findings show incidents of a heart attack, a stroke or a heart-related death among the individuals with drug usage.

Medication used Incidents
Both statin & blood pressure lowering medicine 3.6%
Only statin medicine 3.8%
Only blood pressure lowering medicine 4.6%
Placebos 5.0%

Cholesterol-lowering statins drugs reduce hypertension high blood pressure BP heart attack stroke.

Lead author of the study was Dr. Salim Yusuf, professor of medicine at the McMaster University, Canada and the study findings were published on April 2017 in the New England Journal of Medicine.

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Discovery Of New Type 2 Diabetes (T2D) Loci, Chromosomal or Genetic Locations Among European And African American Communities

Earlier studies had located 76 loci, chromosomal or genetic locations. The researchers believe that these genetic locations were associated with the development of type 2 diabetes (T2D) in individuals. But the number of individuals with type 2 diabetes (T2D) doubles among the African American communities. But very few loci, chromosomal or genetic locations associated with type 2 diabetes (T2D) were found among them.

In a new study done by the researchers from University College London (UCL) and Imperial College London (ICL) have discovered 111 new genetic locations associated with the development of type 2 diabetes (T2D) in the human body. The researchers say some individuals are at enhanced risk of the development of type 2 diabetes (T2D) due to these newly discovered genetic locations. Both European individuals and African American individuals have 93 common gene locations and another 18 gene locations were specific to European individuals. Researchers discovered new genetic locations after studying nearly 6,000 type 2 diabetes (T2D) individuals and another 9,700 healthy individuals.

Type 2 diabetes (T2D) loci chromosomal genetic locations among European African American communities.

The researchers say the newly discovered gene locations can help them in studying and building a more detailed genetic architecture picture of type 2 diabetes (T2D). The same techniques or methods can be used in other complex diseases such as Alzheimer's disease. Co-author of the study was Dr. Nikolas Maniatis and the study findings were published in the American Journal of Human Genetics.

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