Diabetes, Heart, and Cardiovascular Diseases News Chronicle.      Article 201

Statins Can Reduce The Risk Of Heart Attack And Stroke Even In People With Intermediate-Risk

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A study at the McMaster University Hamilton, Ontario, Canada shows a risk reduction to stroke and heart attack in individuals with the cholesterol-lowering statin, even if the risk is moderate. A further risk reduction was observed when a patient with hypertension (high blood pressure. BP) took blood pressure (BP) lowering drug along with a statin. Hypertension in a person can increase the risk of stroke and heart attack.



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Cholesterol-lowering statins can reduce hypertension, high blood pressure, (hypertension. BP) heart attack and stroke.

The HOPE-3 study (Heart Outcomes Prevention Evaluation-3) shows a dual therapy (low-dose statin plus blood pressure lowering therapy) is the best way to reduce the risk of cardiovascular events among older individuals who are with hypertension (high blood pressure. BP) and with just normal cholesterol levels, but having another risk factor such as obesity or smoking.

The HOPE-3 trial showed that the use of statin in more people and study has supported the guidelines of the American Heart Association and the American College of Cardiology. The study showed that statin therapy is safe and effective in lowering the risk of heart attack and stroke in individuals aged over 55 years with intermediate risk factors.


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The 6-year follow-up study involves 12,705 individuals aged over 55 years. All of them are taking some type of medications such as statins, placebos, blood pressure lowering drug. Some patients are taking both statins and blood pressure lowering medications.

The study has found the following percentage of heart attack, stroke or a heart-related death among the patients with drug use.


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A drug used by the patient Incidents
Both statin and blood pressure lowering therapy 3.6%
Only with statin therapy 3.8%
Only blood pressure lowering drug 4.6%
Placebos 5.0%

Lead author of the study was Dr. Salim Yusuf, professor of medicine at the McMaster University, Canada and the study was published in April 2017 in the New England Journal of Medicine. Title of the article is "Cholesterol Lowering in Intermediate-Risk Persons without Cardiovascular Disease."
DOI: doi.org/10.1056/NEJMoa1600176



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Discovery Of New Type 2 Diabetes Loci In European And African American Communities

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An earlier study has found 76 loci, chromosomal or genetic locations. The researchers believe that these genetic locations are associated with the development of type 2 diabetes in an individual.


Type 2 diabetes loci in European and African American communities.

But there is double the number of individuals with type 2 diabetes in the African American communities. But a few genetic loci associated with type 2 diabetes is found among them.



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A study at the University College London (UCL) and Imperial College London (ICL) has discovered 111 new genes associated with the development of type 2 diabetes in the human body. The researchers say that some individuals are at an enhanced risk of the development of type 2 diabetes due to the newly discovered genetic locations.

The study has found 93 common gene locations in the European and the African American individuals and 8 genes specific to the European individuals.

The study involves 6,000 patients of type 2 diabetes and 9,700 healthy individuals.

The researchers say that the newly discovered gene locations can help them in studying and building a more detailed genetic architecture of type 2 diabetes. The same technique (or method) can be used in other complex diseases such as Alzheimer's disease.


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The lead author of the study was Dr. Nikolas Maniatis and the study was published on May 4, 2017, in the American Journal of Human Genetics. Title of the article is "High-Resolution Genetic Maps Identify Multiple Type 2 Diabetes Loci at Regulatory Hotspots in African Americans and Europeans."
DOI: doi.org/10.1016/j.ajhg.2017.04.007



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Published on June 6, 2017

 


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