Fat But Fit And Healthy (Or Obese But Medically Fit) Are At Risk Of Heart Failure And Stroke
An earlier study has indicated that an individual can be metabolically healthy even though that individual is obese. Metabolically healthy, which means an individual with normal blood fats, normal blood sugar (glucose) levels (no diabetes) and normal blood pressure (no hypertension).
In the study, the researchers have reviewed about 3.5 million records over a period of ten years. The study shows "Fat But Fit" is a myth and does not reduce the risk associated with heart failure or stroke.
Individuals with metabolically healthy obesity (MHO) are those individuals who are obese with respect to body mass index (BMI) but no signs of obesity-related problems such as diabetes, blood pressure and blood fats.
A comparative study on heart health among individuals with metabolically healthy obesity (MHO) and individuals with normal body mass index (BMI) has found the following risks or complications among individuals with metabolically healthy obesity (MHO).
The author of the study was Dr. Rishi Caleyachetty, an epidemiologist, the University of Birmingham. The study was presented at the European Congress on Obesity (ECO2017), between 17 and 20 May 2017, at Porto, Portugal. The study was published on September 11, 2017, in the Journal of the American College of Cardiology. Title of the article is "Metabolically Healthy Obese and Incident Cardiovascular Disease Events Among 3.5 Million Men and Women."
The Discovery Of Prkca Gene Which Can Cause Birth Defects And Neural Tube Defects (NTDs) In Pregnant Women With Diabetes
The Prkca gene protein kinase C alpha crRNA, which helps the cells of the body from disposing of the waste matter (a process known as autophagy). A Prkca gene can become overactive and can prevent the autophagy process in a patient of diabetes.
The prevention of the autophagy process can cause the creation of embryonic tissue leading to major birth defects such as neural tube defects.
The researchers from the University of Maryland School of Medicine have discovered the Prkca gene. The Prkca gene can cause neural tube defects (NTDs) in babies born to pregnant women with diabetes. The neural tube defects (NTDs) is a common problem in pregnant women with diabetes. The current discovery can help the researchers to understand and develop new treatments for the prevention of the neural tube defects (NTDs).
The researchers have conducted an experiment with pregnant diabetic mice models by deleting the Prkca gene and allowed autophagy to work normally. They found fewer NTDs in the embryos.
The researchers also conducted an experiment to bring down the level of neural tube defects (NTDs) by altering or by increasing the expression of proteins known as PGC-1alpha in developing neural cells.
The researchers say that the tube defects (TDs) can be stopped or prevented by medications which can help in the prevention of PKCalpha protein or miR-129-2 molecule or activation of PGC-1alpha protein.
The lead author of the study was Professor Peixin Yang, Obstetrics, Gynecology and Reproductive Sciences, the University of Maryland School of Medicine (UM SOM). Other authors include Dean E Albert Reece, MD, Ph.D., MBA, Professor John Z and Professor Akiko K Bowers. The study was published in the journal Nature Communications. Title of the article is "Protein kinase C-alpha suppresses autophagy and induces neural tube defects via miR-129-2 in diabetic pregnancy."
Neural tube defects: Neural tube defects (NTDs) are birth defects which may impact the brain and in the spinal cord during the first month of pregnancy. At that moment, pregnant women do not know that she was pregnant.
An earlier study shows consuming vitamin B9, folate or folic acid supplements before and during pregnancy can reduce neural tube defects (NTDs). About 95 percent of the neural tube defects (NTDs) of the babies can be diagnosed with the ultrasound scan between 18 and 20 weeks of the pregnancy.
The common cause for the neural tube defects (NTDs) in babies born is due to the obesity, folic acid deficiency and diabetes in pregnant women.
An earlier study shows that about ten percent of the babies of diabetic pregnant women may suffer from neural tube defects.
Another study shows about three to ten times enhanced risk of neural tube defects (NTDs) in women with diabetes (diabetes prior to pregnancy) when compared with women without diabetes.
Neural tube defects (NTDs) affect nearly 300,000 pregnant women globally every year and nearly ten percent of the babies with the neural tube defects (NTDs) may die within a year.
The Diabetes News Chronicle does not provide medical advice, diagnosis or treatment. Information in Diabetes News Chronicle is to support and not to replace medical advice given by the surgeon or physician or doctor. The published article is not a medical advice by the OWNER of the "Diabetes News Chronicle" website or by the AUTHOR of the article.
Published by Jammi Vasista, Chennai, India.