BCG Vaccine Could Restore Proper Immune Response In Patients With Type 1 Diabetes
A new FDA-approved clinical trial on mice models suffering from an advanced type 1 diabetes (T1D) at the Massachusetts General Hospital, the United States shows the restoration of immune response for the secretion of insulin with the genetic vaccine Bacillus Calmette-Guerin (BCG).
The researchers have developed this vaccine by using a harmless strain of bacteria, which can cause tuberculosis. The vaccine was approved earlier by the United States FDA for the treatment of bladder cancer.
Type 1 diabetes (T1D) is caused due to the attack of T cells (Tregs) on the immune system. The researchers say that the genetic vaccine Bacillus Calmette-Guerin (BCG) can restore a permanent gene expression and can restore T cells (Tregs).
The researchers have completed a successful reversal of type 1 diabetes (T1D) on mice models. The subsequent trial on humans with the BCG vaccine is successful and the study results were expected by the end of 2017.
Now the researchers are enrolling 150 adult patients with type 1 diabetes (T1D) for a five-year Phase II trial of BCG vaccine. They wanted to see the improvement or reversal of type 1 diabetes (T1D) with a repeated BCG vaccination.
The principal investigator of the study was Dr. Denise Faustman, Ph.D., Director, Immunology Laboratory, the Massachusetts General Hospital, Boston, the United States. The study was presented at the 75th Scientific Sessions of the American Diabetes Association.
Excess Weight May Reduce The Early Risk Of Death For Elderly People With Diabetes
A study at the Capital Medical University, Beijing, China on elderly people with diabetes shows 18 percent lower early risk of death and extend the lifespan of individuals with excess body weight (higher body mass index. BMI).
An earlier study shows that obesity can cause adverse health risks. But this study shows the benefits to older adults with diabetes during later life by keeping excess weight.
The researchers came to this conclusion after analyzing data of about 250,000 patients with type 1 diabetes (T1D) or type 2 diabetes (T2D) from 20 studies.
The researchers have assessed the body mass index (BMI) of the participants and investigated the association between BMI and the risk of all-cause mortality. The follow-up study was done between 2.9 and 16.7 years.
But, the researchers have been unable to explain the link between longer lifespan in later life and overweight for older adults patients with diabetes.
An earlier study shows an inverse association between insulin resistance and muscle mass. The weight can reduce as the lean muscle mass reduces with age. Body weight loss in older adults could lead to worse health outcomes.
The co-author of the study was Yu Jie Zhou, from An Zhen Hospital, the Capital Medical University, Beijing, China. The study was published in the Journal of Diabetes Investigation. Title of the article was "Impact of obesity on mortality in patients with diabetes: Meta-analysis of 20 studies including 250,016 patients".
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Published by Jammi Vasista, Chennai, India.