Diabetes, Heart, and Cardiovascular Diseases News Chronicle.      Article 220

A Study Shows Lower Levels Of Vitamin A Can Cause Diabetes

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A study shows a reduction in the secretion of insulin with the blockage of vitamin A receptors on the surface of beta cells, called GPRC5C. They say that a new diabetes treatment can be developed with this discovery, by targeting GPRC5C in the pancreas.



A study shows lower levels of vitamin A can cause type 1 and type 2 diabetes.

The researchers have found vitamin A receptors on the surface of the beta cells. The researchers have conducted an experiment on mice models to know how vitamin A receptors in the beta cell will interact with vitamin A.


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A study on mice models has found a reduction in the ability of the beta cells in secreting insulin in response to sugar (glucose) level with a partial blockage of vitamin A receptors.

The study on humans with and without type 2 diabetes, the study has found a 30 percent reduction in insulin secretion, when they partially blocked GPRC5C (in beta cells) and applied sugar on them.

With these experiments, they believe that the lack of vitamin A can cause a reduction in insulin secretion and vitamin A can play a role in the development of type 2 diabetes (T2D).

This study also suggests that the role of vitamin A in the development of type 1 diabetes (T1D). The destruction of insulin-secreting beta cells in the pancreas can cause type 1 diabetes.



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They say that children need a sufficient quantity of vitamin A to prevent the development of diabetes. An experiment on newborn mice models shows the need for vitamin A for the normal growth of beta cells. But they say that not to increase the intake of vitamin A through supplements as excess vitamin A levels are associated with health problems such as osteoporosis.

Now the researchers are finding ways to activate GPRC5C, to improve the function of beta cells to secrete more insulin without causing side effects associated with vitamin A.

The co-author of the study was Albert Salehi, Lund University, Sweden. The study was published in the Japan Endocrine Society. Title of the article was "Anti-diabetic action of all-trans retinoic acid and the orphan G protein-coupled receptor GPRC5C in pancreatic β-cells".
DOI: doi.org/10.1507/endocrj.EJ16-0338



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Protection To Type 2 Diabetes With Broccoli Sprout Extract (BSE) Which Contains Sulforaphane (SFN)

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Vegetables such as cabbage, broccoli and brussels sprouts contain a compound called sulforaphane (SFN). This compound is being used for the treatment of cancer and chronic obstructive pulmonary disease (COPD). SFN treatment can also protect other health complications such as renal failure, neuropathy and atherosclerosis.


Protection to type 2 diabetes with broccoli sprout extract (BSE) which contains sulforaphane (SFN).

A study shows the regulation of blood sugar (glucose) levels (HbA1c) of a patient with type 2 diabetes (T2D) with a concentrated broccoli sprout extract.



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The researchers have conducted experiments with sulforaphane (SFN) on mice and rat models. The study shows a reduction in glucose production by the liver cells and the changes in the gene expression associated with diabetes.

To know the human body glucose metabolism with sulforaphane (SFN), they have conducted an experiment on 103 obese individuals with uncontrolled high blood sugar (glucose) level. The study participants were on either placebo or on broccoli sprout extract (BSE) (which contains sulforaphane. SFN) for 12 weeks. The researchers have observed the effects of broccoli sprout extract (BSE) on blood sugar levels, side effects and other symptoms.

The study shows a significant reduction in blood sugar (glucose) levels (and HbA1c) without serious side effects with the use of broccoli sprout extract (BSE).


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But the authors are not recommending the broccoli sprout extract (BSE) as drug treatment to patients with type 2 diabetes (T2D) as a further study is required.

About 75 percent of the participants in the study are male, aged between 35 and 75 years. The participants have consumed the refined broccoli sprout extract (BSE).

The study was published in the journal Science Translational Medicine. Title of the article was "Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes".
DOI: doi.org/10.1126/scitranslmed.aah4477



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Published on August 2, 2017

 


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