A study at the Washington University School of Medicine, St Louis, United States shows an increased risk of type 1 diabetes (T1D) in children (kids or teens) with the intestinal virus. The intestinal virus generates new antibodies in children with a less diverse population of gut bacteria. The study also shows a less likely risk of type 1 diabetes (T1D) in children who are with the virus belonging to the circoviridae family in their intestine.
The researchers say that they have identified two groups of viruses. One group viruses can help us in lowering the risk of type 1 diabetes (T1D). Another group of the virus will produce antibodies that work against our cells and they are associated with a higher risk of type 1 diabetes.
The researchers think that the balance of these two groups of the virus may determine the development of type 1 diabetes (T1D) in the children. They also think that the circovirus can help the children in preventing type 1 diabetes. The researchers say that the circoviruses (the small viruses) may help in preventing the development of type 1 diabetes (T1D) in the children who are at high risk of type 1 diabetes (T1D).
The first author of the study was Dr. Guoyan Zhao, Ph.D., Assistant Professor, Department of Pathology & Immunology, Washington University School of Medicine. The lead author of the study was Dr. Herbert 'Skip' Virgin IV, MD, Ph.D., Department of Pathology & Immunology, Washington University School of Medicine. The study was published on July 25, 2017, in the journal Proceedings of the National Academy of Sciences (PNAS). Title of the article was "Intestinal virome changes precede autoimmunity in type I diabetes-susceptible children".
There is no study on the association between type 2 diabetes (T2D) and the oral microbiome. An earlier report from the American Academy of Periodontology and the European Federation of Periodontology says there is no evidence that shows high blood sugar (glucose) levels (type 2 diabetes) can cause the changes in the oral microbiome.
A new study at the University of Pennsylvania shows the risk of periodontitis (a common inflammatory disease) in patients with type 2 diabetes (T2D) and the significance of keeping healthy teeth in patients with type 2 diabetes (T2D).
An experiment on mice models with type 2 diabetes shows the shifting of oral microbiome (with a less diverse population of bacteria) is associated with bone loss and increased inflammation. The study shows an increase in the level of IL-17 (interleukin-17) protein and the risk of periodontitis with hyperglycemia (associated with type 2 diabetes). Periodontal disease in humans is associated with increased levels of IL-17 (interleukin-17 protein).
The National Health Service (NHS) says that periodontal disease can cause the gums to bleed, an unlikable food taste, loss of teeth, bad breath and the formation of pus in gums or in the bones that hold the teeth.
The senior author of the study was Professor Dana T Graves, DDS, DMSc, Department of Periodontics, Penn Dental Medicine, the University of Pennsylvania. The study was published on July 12, 2017, in the journal Cell. Title of the article was "Diabetes Enhances IL-17 Expression and Alters the Oral Microbiome to Increase Its Pathogenicity".
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Published by Jammi Vasista, Chennai, India.