Diabetes, Heart and Cardiovascular Diseases News Chronicle.  Diabetes, Cardiovascular and Heart Diseases
 Article 227
    Published on August 17, 2017

 

The risk of type 1 diabetes in children with the intestinal virus

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A study at the Washington University School of Medicine, St Louis, United States shows an increased risk of type 1 diabetes (T1D) in children (kids or teens) with an intestinal virus. The intestinal virus generates new antibodies among children with a less diverse population of gut bacteria. The study also shows a less likely risk of type 1 diabetes (T1D) in children who are with a virus belonging to the circoviridae family in their intestine.



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The intestinal virus may cause type 1 diabetes in children (kids or teens).

Researchers say they identified two groups of viruses. One group viruses can help us in lowering the risk of type 1 diabetes (T1D). Another group of virus will produce antibodies that work against our cells and they are associated with a higher risk of type 1 diabetes. Researchers think the balance of these two group of virus may determine the development of type 1 diabetes (T1D) in the children. They also think that circovirus can help children in preventing type 1 diabetes. The researchers say that circoviruses (small viruses) may help in preventing the development of type 1 diabetes (T1D) in children who are at a high risk of type 1 diabetes (T1D).


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The first author of the study was Dr. Guoyan Zhao, Ph.D., Assistant Professor, Department of Pathology & Immunology, Washington University School of Medicine. The lead author of the study was Dr. Herbert 'Skip' Virgin IV, MD, Ph.D., Department of Pathology & Immunology, Washington University School of Medicine. The study was published on July 25, 2017, in the journal Proceedings of the National Academy of Sciences (PNAS). Title of the article was "Intestinal virome changes precede autoimmunity in type I diabetes-susceptible children".



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Higher risk of periodontitis, gum or tooth disease in patients with type 2 diabetes

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There is no study on the association between type 2 diabetes (T2D) and the oral microbiome. An earlier report from the American Academy of Periodontology and the European Federation of Periodontology says there is no evidence that shows high blood sugar (glucose) levels (type 2 diabetes) causes changes in the oral microbiome.


Higher risk of periodontitis, gum or tooth disease in patients with type 2 diabetes.

A new study at the University of Pennsylvania shows the risk of periodontitis (a common inflammatory disease) in patients with type 2 diabetes (T2D) and the significance of keeping healthy teeth in patients with type 2 diabetes (T2D).



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Experiment on mice models with type 2 diabetes shows the shifting of oral microbiome (with a less diverse population of bacteria) is associated with the bone loss and increased inflammation. The study shows an increase in the levels of IL-17 or interleukin-17 protein and the risk of periodontitis with type 2 diabetes (T2D) or hyperglycemia. Periodontal disease in humans is associated with increased levels of IL-17 or interleukin-17 protein.

The NHS, says periodontal causes gums to bleed, causes an unlikable food taste, loss of teeth, bad breath and the formation of pus in gums or in the bones that hold teeth. Senior author of the study was Professor Dana T Graves, DDS, DMSc, Department of Periodontics, Penn Dental Medicine, the University of Pennsylvania.



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