Diabetes, Heart, and Cardiovascular Diseases News Chronicle.      Article 233

Tick Saliva Can Prevent The Viral Heart Disease (Myocarditis) And Inflammation

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The tick bite generally does not cause pain, itching or irritation. About 3,000 proteins found in tick saliva could be used to prevent inflammation in the area of the bite.


Tick saliva can prevent the Viral heart disease (myocarditis) and inflammation.

A study at Oxford University, New Orleans, Louisiana, the United States, shows an innovative treatment to the dangerous heart diseases with the saliva from ticks. The researchers say that the new drugs and a life-saving therapy can be developed with the saliva from ticks. The saliva from ticks can also be used for the treatment of diseases such as heart diseases, pancreatitis, arthritis and stroke.



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The heart inflammation such as myocarditis can be prevented excellently with the proteins found in the saliva from ticks. An earlier study shows that chemokines (or cytokines) cause inflammation in the heart (myocarditis) leading to heart failure. The treatment for the inflammation of the heart is the key to the prevention of heart failure. The cells of our immune system will produce the small protein molecules called as chemokines. But there is no treatment option for the myocarditis.

Up to 3,000 proteins are present in the saliva from ticks, which can prevent the pain or inflammation in the heart as they can neutralize chemokines chemicals. The current study shows the production of tick saliva proteins in the laboratory and an injection of the tick proteins into the humans for the prevention of inflammation in the organs such as the heart. There are possibilities in developing a pill containing nanoparticles solution composed of tick proteins. Now, the researchers are using the yeast to grow the proteins of tick saliva from the synthetic gene to produce the proteins in very large amounts.


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The co-author of the study was Professor Shoumo Bhattacharya, MD, Department of Cardiovascular Medicine, the University of Oxford, Oxford. The study was published June 27, 2017, in the journal Scientific Reports. Title of the article was "Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities."
DOI: doi.org/10.1038/s41598-017-04378-1



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The Risk Of Left Ventricular Hypertrophy (LVH) And Heart Failure In A Patient With A History Of Asthma

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Around 25 million people are suffering from asthma in the United States. An earlier study shows an increased risk of heart attack, stroke, heart disease and cardiovascular diseases in a patient suffering from asthma. A current study at the Tulane University Obesity Research Center (TUORC) shows a greater risk of left ventricular hypertrophy (LVH) in a patient with a history of asthma.



The risk of left ventricular hypertrophy (LVH) and heart failure in a patient with a history of asthma.

During a 10-year follow-up study, the researchers have assessed the health data of 1,118 participants of the Bogalusa Heart Study. They have collected the history of asthma from the childhood of the participant. The researchers have assessed the size of the left ventricle with the help of echocardiography. They calculated the left ventricular mass index (LVMI) from the left ventricular mass (LVM) and height.


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When the researchers looked into the records of individuals suffering from respiratory diseases, the researchers have found a higher adjusted mean left ventricular mass (LVM) and a higher left ventricular mass index (LVMI) in individuals with a history of asthma. The researchers also found a link between left ventricular mass index (and also left ventricular mass) and the history of asthma in individuals with higher systolic blood pressure. The study results accounted for risk factors such as cardiovascular diseases (CVD), age, use of other blood pressure medication, heart rate, smoking.

To lower the risk associated with cardiovascular diseases in individuals with a history of asthma, the researchers say that patients should adopt aggressive lifestyle changes or even a pharmacological (a study of drug action) treatment, especially in patients of high blood pressure.


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Now, the researchers are planning a further study to find out an exact association between asthma and death, myocardial infarction, heart failure and stroke.

The senior author of the study was Dr. Lu Qi from the Tulane University Obesity Research Center (TUORC), New Orleans, LA, the United States. The study was published June 26, 2017, in the Journal of the American College of Cardiology JACC: Heart Failure. Title of the article was "A History of Asthma From Childhood and Left Ventricular Mass in Asymptomatic Young Adults."
DOI: doi.org/10.1016/j.jchf.2017.03.009



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Published on August 26, 2017

 


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