Tick saliva prevents killer myocarditis heart condition
Ticks bite don't cause pain, itching or irritation as they discharge multiple proteins which prevent local inflammation. A study by the researchers at the Oxford University shows treatment to dangerous heart diseases with ticks saliva. Researchers say new drugs and life-saving therapies can be developed with the saliva of ticks, which is a "gold mine" for the development of new drugs. Tick saliva can also be used to treat diseases such as heart diseases, pancreatitis, arthritis and stroke.
Heart inflammation such as myocarditis can be stopped excellently with the proteins found in the tick saliva. Earlier studies show inflammation in the heart due to chemokines causes myocarditis leading to heart failure. Treating heart inflammation is the key to this treatment. Cells of our immune system produce small protein molecules called chemokines. But there are no treatment options for myocarditis.
Up to 3,000 proteins present in the saliva of ticks prevents pain or inflammation as they neutralize chemokines. The current study shows purified and tick proteins being cultivated in the laboratory can be injected into humans to prevent inflammation in organs such as the heart. There are possibilities in making pills which contain nanoparticles composed of tick proteins. Now the researchers are using yeast to grow tick saliva proteins from synthetic genes to make very large amounts.
Co-author of the study was Professor Shoumo Bhattacharya, MD, Department of Cardiovascular Medicine, University of Oxford, Oxford. The study findings were published June 27, 2017, in the journal Scientific Reports. Title of the article was "Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities."
Risk of left ventricular hypertrophy (LVH) and heart failure with asthma history
Around 25 million people are suffering from asthma in the United States. Earlier studies show an increased risk of heart attack, stroke, heart disease and cardiovascular diseases with asthma. A current study by researchers at the Tulane University Obesity Research Center (TUORC) shows a greater risk of left ventricular hypertrophy (LVH) with a history of asthma.
Researchers assessed health data of 1,118 Bogalusa Heart Study participants. They collected asthma history of the participants from childhood. During a 10-year follow-up studies, researchers assessed the size of the left ventricle using echocardiography. They calculated a left ventricular mass index (LVMI) after accounting their LVM with height. Compared with individuals without asthma history, researchers found higher adjusted mean LVM and higher LVMI in individuals with respiratory condition among asthma history individuals. The researchers also found a link between greater LVMI (and also LVM) and asthma history among individuals with higher systolic blood pressure. The study findings were accounted other risk factors such as cardiovascular diseases (CVD), age, usage of other blood pressure medication, heart rate, smoking etc.
The researchers say to reduce risk associated with cardiovascular diseases among individuals with a history of asthma, patients should adopt aggressive lifestyle changes or even pharmacological (a study of drug action) treatment. It is even more important for a history of asthma individual affected with high blood pressure. Researchers are planning further studies to find out an exact association between asthma and death, myocardial infarction, heart failure and stroke. Senior author of the study was Dr. Lu Qi from The Tulane University Obesity Research Center (TUORC), New Orleans, LA, United States. The study findings were published June 26, 2017, in the Journal of the American College of Cardiology JACC: Heart Failure. Title of the article was "A History of Asthma From Childhood and Left Ventricular Mass in Asymptomatic Young Adults."
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Published by Jammi Vasista, Chennai, India.