A study at the China Medical University, Taiwan shows the increased risk of Alzheimer's (or brain dysfunction) later in the life of individuals with type 2 diabetes (T2D), aged more than 60 years (elderly), with a high visit-to-visit variations in the blood sugar (glucose) levels (fasting plasma glucose. FPG). Intellectual impairment and memory loss are the characteristics of Alzheimer's disease.
The study shows a high variation in blood sugar (glucose) level at the closer intervals (or visits) may be more worrying compared to a low variation in blood sugar (glucose) levels for the brain function for old age (elderly) individual.
A study on 16,706 individuals with type 2 diabetes (T2D) but without the signs of Alzheimer's disease, aged more than 60 years (old aged) shows the risk of Alzheimer's disease. All risk factors are under the control of the participants except the variations in the blood sugar (glucose) levels.
They noted HbA1c and fasting blood sugar levels at the start of the study. They tracked the HbA1c and fasting blood sugar levels for more than 8.88 years. They noted a change in the reading over the previous visit during the study period. Alzheimer's disease was identified in 831 individuals in the study. They noted that Alzheimer's disease affects 0.35 percent of individuals per year.
The study results accounted for confounders (diabetes-related factors) such as lifestyle behavior factors and sociodemographic factors, the study shows that Alzheimer's disease was associated with the high variations in blood sugar levels between visits (visit-to-visit) in either HbA1c levels or fasting blood sugar levels (or both of them).
A previous study published in 2014 in the Journal of Alzheimer's Disease shows an improvement in the brain health of an individual with a healthy lifestyle. Another study at the University of California (UCSF), San Francisco, shows low education is the biggest risk factor for the Alzheimer's disease, followed by a smoking habit, couch potato (sedentary lifestyle) behavior, depression, high blood pressure (hypertension. BP), diabetes (high blood sugar levels) and obesity (overweight). In that study, researchers have found a 50 percent of the Alzheimer's disease is associated with the lifestyle risk factors and most of these factors can be managed or can be prevented.
The author of the study was Tsai-Chung Li, Ph.D., Principal Investigator, China Medical University, Taiwan. The study was published July 2017 in the journal Diabetes Care. Title of the article was "Visit-to-Visit Variations in Fasting Plasma Glucose and HbA1c Associated With an Increased Risk of Alzheimer Disease: Taiwan Diabetes Study."
An analysis of the past studies has found that sexual disorder or erectile dysfunction is affecting about 53 percent of patients with diabetes. The erectile dysfunction may start developing between 10 and 15 years earlier in male patients with diabetes compared with people without diabetes.
The researchers have analyzed the health records of 88,577 men from 145 studies. The study has found that patients with diabetes are at three and a half times higher risk of erectile dysfunction compared to individuals without diabetes. The study shows 37.5 percent of the patients with type 1 diabetes (T1D) and 66.3 percent of patients with type 2 diabetes (T2D) are affected with erectile dysfunction.
The researchers say that healthcare professionals should screen patients with erectile dysfunction for possible heart disease as erectile dysfunction is a sign of cardiovascular diseases. They also say that the screening for erectile dysfunction should be done as a part of a routine assessment of a male patient with diabetes.
The co-author of the study was Dr. Damiano Pizzol, Operative Research Unit, Doctors with Africa CUAMM (a non-governmental organization in the field of healthcare), Beira, Mozambique. The study was published on July 18, 2017, in Diabetic Medicine. Title of the article was "High prevalence of erectile dysfunction in diabetes: a systematic review and meta-analysis of 145 studies."
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Published by Jammi Vasista, Chennai, India.