A study done by the researchers at the China Medical University, Taiwan shows increased risk among type 2 diabetes (T2D) individuals, aged more than 60 years (elderly) with the development of Alzheimer's disease (or brain dysfunction) later in life with high visit-to-visit variations in the blood sugar or glucose levels (fasting plasma glucose FPG). Intellectual impairment and memory loss are the characteristics of Alzheimer's disease. Their study shows high variations in blood sugar (or glucose) levels at close intervals (or visits) may be more worrying compared to small changes in those levels for brain integrity in old age or elder individuals.
Researchers studied 16,706 type 2 diabetes (T2D) individuals without signs of Alzheimer's disease, aged more than 60 years (old age). All risk factors are under control in the participants except blood sugar or glucose variations. They noted HbA1c and fasting blood sugar or glucose levels at the start of the study. They tracked HbA1c and fasting blood sugar or glucose levels for more than 8.88 years. They noted a change in the reading over the previous visit during the study period. Alzheimer's disease was identified in 831 individuals over the eight years study period. They noted that Alzheimer's disease was affected 0.35 percent of individuals per year. After adjusting factors such as diabetes-related variables, lifestyle behavior factors and sociodemographic factors, their study results show Alzheimer's disease was associated with high visit-to-visit variations in either HbA1c levels or fasting blood sugar levels (or both of them).
A previous study published in the year 2014 in the Journal of Alzheimer's Disease shows improvement in brain health of an individual with a healthy lifestyle. Another earlier study from the University of California (UCSF), San Francisco shows low education is the biggest risk factor for the Alzheimer's disease, followed by smoking habit, leading a couch potato or sedentary lifestyle, depression, high blood pressure (BP) or hypertension, diabetes or high blood sugar or glucose levels and obesity or overweight. In that study, researchers found 50 percent of the risk of the development of Alzheimer's disease is associated with lifestyle-related risk factors and most of these factors can be managed or can be prevented.
Author of the study was Tsai-Chung Li, Ph.D., Principal Investigator, China Medical University, Taiwan. The study findings were published on July 2017 in the journal Diabetes Care. Title of the article was "Visit-to-Visit Variations in Fasting Plasma Glucose and HbA1c Associated With an Increased Risk of Alzheimer Disease: Taiwan Diabetes Study."
An analysis of past studies done by the researchers found that sexual disorder or erectile dysfunction is affecting about 53 percent of the diabetic men. Erectile dysfunction condition develops 10 to 15 years earlier in diabetic men compared with non-diabetic men.
Researchers analyzed 145 studies containing health records of 88,577 men and found that diabetic individuals are at three and a half times higher risk for maintaining erection compared to individuals without diabetes. The study shows 37.5 percent of type 1 diabetes (T1D) individuals and 66.3 percent of type 2 diabetes (T2D) individuals were affected with erectile dysfunction. Researchers say healthcare professionals should screen erectile dysfunction patients for a possible heart disease as erectile dysfunction is a sign of the silent cardiovascular diseases. They also say erectile dysfunction screening should be done as a part of a routine assessment of a diabetic male individual.
Co-author of the study was Dr. Damiano Pizzol, Operative Research Unit, Doctors with Africa CUAMM (a non-governmental organization in the field of healthcare), Beira, Mozambique. The study findings were published on July 18, 2017, in the Diabetic Medicine. Title of the article was "High prevalence of erectile dysfunction in diabetes: a systematic review and meta-analysis of 145 studies."
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Published by Jammi Vasista, Chennai, India.