Damage to the heart muscle due to coronary artery disease (CAD) causes heart failure. Quick help and medical treatment can minimize damage to heart muscle. Less damage to heart muscle improves the life expectancy of a heart patient. Most heart attack patients can start their normal work between a couple of weeks to three months.
A study done by Australian researchers at the Baker Heart & Diabetes Institute shows heart cell death prevention following a heart attack with a single injection of HDL or GOOD cholesterol. Researchers believe that the number of premature deaths due to heart failure caused by the heart attack can be reduced by treating them with HDL cholesterol.
Researchers have conducted a preclinical trial with mouse models. They treated them with a single injection of "GOOD" or HDL cholesterol immediately after a heart attack. Their study demonstrated prevention death of heart tissue and cells and improved heart function with a single injection of "GOOD" or HDL cholesterol. Researchers say heart muscle absorbs more glucose with an HDL cholesterol injection.
Lead researcher of the study was Professor Bronwyn Kingwell, BSc(Hons), PhD, an integrative physiologist and NHMRC Senior Principal Research Fellow, Baker Heart & Diabetes Institute, Australia.
A heart attack is caused due to high cholesterol and hypertension or high blood pressure (BP) levels. Some part of the heart tissue will be replaced with a dead tissue with scars made of cells even if an individual survives a heart attack. These dead tissues with scars do not help the heart in pumping blood and may weaken the heart function.
The objective of this study was to restore heart function by reprogramming scar tissue of the heart into cardiac muscle cells (myocardiocytes, cardiomyocytes, or cardiac myocytes) which make up the heart muscle. They found that a GATA4 transcription factor protein can prevent the damage to heart cells and tissue and prevents weakening of the heart function.
In experiments with small animal models with a heart attack, a cocktail of Mef2c, GATA4 and Tbx5 (GMT) transcription factor proteins treatment resulted in less scar tissue in the heart muscle and up to 50 percent improvement in heart function.
Author of the study was Dr. Megumi Mathison, MD, PhD, Associate Professor of Surgery, Baylor College of Medicine, Houston, Texas. The study findings were published on August 15, 2017, in the Journal of Thoracic and Cardiovascular Surgery. Title of the article was "Cardiac reprogramming factor Gata4 reduces postinfarct cardiac fibrosis through direct repression of the profibrotic mediator snail."
Transcription factor : A transcription factor (TF) molecules are important for the normal development of the organism, in response to diseases and regular cellular functions. Gene's activity is controlled by a transcription factor (TF) (or sequence-specific DNA-binding factor) molecule. They bind to specific sites and determine whether gene's DNA (deoxyribonucleic acid) can be copied into RNA (ribonucleic acid). The rate of transcription of genetic information to RNA from DNA will be controlled by transcription factor (TF). RNA (Ribonucleic acid) molecule plays multiple biological roles. Efficiency and functionality of the RNA (Ribonucleic acid) molecule will be controlled by transcription factor (TF) molecule. A paper published during 2002 estimated between 2000 and 3000 transcription factor (TF) molecules in the human body.
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Published by Jammi Vasista, Chennai, India.