Diabetes, Heart and Cardiovascular Diseases News Chronicle.  Diabetes, Cardiovascular and Heart Diseases
 Article 260
    Published on October 23, 2017

Weight loss and improved blood sugar glucose levels (glycemic control) with an EndoBarrier device

A NHS trial for the treatment of type 2 diabetes (T2D) done by the doctors at the City Hospital, Birmingham, England, shows improvement in the blood sugar levels and significant amount of weight loss with a new EndoBarrier device among overweight, obese or higher BMI patients with an uncontrolled type 2 diabetes (T2D).

The EndoBarrier device is a very thin log plastic tube or sleeve as illustrated in the image. This device will be unrolled into the small intestine passed down into the mouth. This device stops the absorption of excess calories from the food which we eat through its lining. This procedure is an endoscopic procedure and does not involve surgery. This device usually removed after 12 months.

Doctors have conducted trials with EndoBarrier device among 50 patients who are with uncontrolled type 2 diabetes (T2D) for 17 years. Seventeen patients among them are under insulin treatment. The trial results with the EndoBarrier device shows

  • Improved insulin sensitivity resulting in healthy blood sugar or glucose levels (lower glycemia or HbA1c levels)
  • Improved islet function resulting in improved insulin secretion. Insulin dosage was reduced from 100 units to 30 units per day among insulin-dependent type 2 diabetes patients (T2D)
  • Reduction in the need for oral diabetes medications
  • A decrease in the blood pressure
  • A decrease in the fat deposits in the liver
  • Stimulation of gut to release more hormone
  • Weight loss of 15 kg (33 lb)
  • Improvement in the fitness levels

Weight loss improved blood sugar glucose levels glycemic control or HbA1c with an EndoBarrier device.

This study shows the health benefits of the EndoBarrier device are similar to the health benefits of gastric bypass surgery. The latest study findings were presented at the annual meeting of the European Association for the Study of Diabetes (EASD), Lisbon, Portugal. Even though the results are promising, doctors say further studies are required to find out long-term effects on the weight loss and blood sugar or glucose levels (HbA1c levels) management with the EndoBarrier device.

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Lose 15 kg (33 lb) in body weight (weight loss) by eating a low-calorie diet to reverse type 2 diabetes and extend life expectancy by six years

Experts say sustained body weight loss of around 15 kg or 33 lb by eating low-calorie diet can cure or reverse type 2 diabetes (T2D). But most of the patients do not try to lose weight. Even if a patient achieves remission (no longer having diabetes) of type 2 diabetes (T2D) by losing weight, patient and healthcare professional of the patient seldom acknowledge the achievement and record the remission of type 2 diabetes (T2D) condition.

The current guidelines advise diabetic patients to reduce risks associated with cardiovascular diseases and high blood sugar or glucose levels with drugs and lifestyle changes. Researchers say life expectancy will be shorter by up to six years and a higher risk of the development of health complications in diabetic patients compared with non-diabetic patients. Earlier studies show the life expectancy of an individual with diabetes can be extended with weight loss.

Weight loss by eating a low-calorie diet to reverse type 2 diabetes extend life expectancy six years.

Lead author of the study was Louise McCombie, RD Weight Management Specialist, School of Medicine, Dentistry & Nursing, the University of Glasgow, United Kingdom. The study findings were published on September 13, 2017, in the British Medical Journal (BMJ). Title of the article was "Beating type 2 diabetes into remission."

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