Diabetes, Heart and Cardiovascular Diseases News Chronicle.  Diabetes, Cardiovascular and Heart Diseases
 Article 261
    Published on October 24, 2017

 

Cholesterol crystals are a sure sign of an imminent heart attack and stroke

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Scientists at the Michigan State University, United States say that the cholesterol crystals in the arteries and in the heart are a sure sign of an imminent heart attack or stroke. The danger signals sent by the cells affected by the cholesterol crystals cause inflammation and hardening of the walls of the arteries. These cholesterol crystals are formed by calcium, fat and other substances, begins during the early stages of the development of the heart diseases.



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The cholesterol crystals formed with fat, calcium and cholesterol can damage the artery walls, disrupt the plaque and can activate a biomarker called NLRP3.

Scientists found the hardened cholesterol crystals in the arteries (and even in the heart) of over 89 percent of the emergency department patients. They can break the plaque formed in the arteries and reaches the heart. Scientists say that the size of the cholesterol increases when it converts into a solid (crystal) form from a liquid form (similar to increase in the volume in the formation of the ice from the water). The cholesterol crystals formed in the bloodstream can tear and damage the artery wall. Disruption of plaque can lead to the formation of clots causing a heart attack. Apart from causing physical damage to the artery walls, these cholesterol crystals can activate a biomarker called NLRP3 and produce Interleukin-1 (IL-1). Interleukin-1 causes inflammation and worsens the condition of the coronary arteries.


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Scientists say the damage to the heart can be reduced by treating and dissolving the cholesterol crystals in the arteries and in the heart by developing new treatments. The cholesterol levels in the body can be reduced with foods such as chia seeds, wheat bran, fenugreek seeds, oats and walnuts. An earlier study shows a regular physical exercise, proper treatment and a healthy diet can lower the risk of the formation of cholesterol crystals in the arteries.


The leader of the study was Dr. George S. Abela, MD, MS, a professor of Medicine, Michigan State University. The study was published on November 15, 2017, in the American Journal of Cardiology. Title of the article was "Frequency of Cholesterol Crystals in Culprit Coronary Artery Aspirate during Acute Myocardial Infarction and Their Relation to Inflammation and Myocardial Injury."



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Carotid Artery Disease

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The carotid artery disease is a type of cardiovascular disease caused when the carotid artery, which supplies the blood to the brain will be blocked or narrowed due to the plaque formation. Between 20 and 30 percent of the stroke hospitalizations and death falls under the category of the carotid artery disease. The carotid artery disease is a fifth leading cause of death in the United States. The main risk factors associated with the carotid artery disease are.



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  • Tobacco use.
  • High blood pressure (hypertension. BP).
  • High cholesterol levels.
  • High blood sugar (glucose) levels (type 2 diabetes).
  • Family history.

The carotid artery disease (a type of cardiovascular disease) is caused when the plaque blocks the blood supply to the brain.

Generally, carotid artery disease will be discovered when the patient suffers a transient ischemic attack (TIA) or a stroke. The carotid artery blockage or disease can also be detected by observing the neck with a stethoscope. The blockage of an artery and severity can be diagnosed by using the ultrasound, CT angiograms or MRA scan (MR Angiography or Magnetic Resonance Angiogram). The carotid angioplasty, carotid endarterectomy or stenting procedures are used for the carotid artery disease.



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Transient ischemic attack : It is also called as a mini-stroke. The non-functioning of a part of the brain, retinal or spinal cord caused due to the temporary (one minute on average) loss of blood flow but without the death of the tissue (infarction) is called Transient Ischemic Attacks (TIA). Temporary loss of blood is caused due to the arterial plaque formed in the smaller arteries of the brain. The affected individual may experience temporary loss of hearing/smell/blindness, mental confusion, slurred speech (dysarthria) or aphasia (a communication disorder). TIA symptoms will disappear within 24 hours. Transient Ischemic Attacks (TIA) may be single or multiple events and they are the warning signs of a stroke.


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