Diabetes, Heart and Cardiovascular Diseases News Chronicle.  Diabetes, Cardiovascular and Heart Diseases
 Article 263
    Published on October 26, 2017

Self-expanding (SE) stents outperform balloon-expandable (BE) stents for treating iliac artery (atherosclerosis) disease

A study done by researchers at the Asklepios Klinikum Harburg, Hamburg, Germany, shows atherosclerosis condition in the iliac arteries can be treated effectively with self-expanding (SE) stents when compared to balloon-expandable (BE) stents. Endovascular surgery or treatments are less invasive and preferred in the treatment of aortoiliac lesions and iliac artery stenting. But there is no information which shows the best type of stent to be used in above treatments.

Researchers have conducted studies to find out the effective stent with 660 patients under treatment with peripheral artery disease (Rutherford state 1 to 4), in northern Europe (German and Swiss centers) between August 2010 and June 2013. The study results show self-expanding (SE) stents for the treatment of iliac artery occlusive disease led to decrease in the restenosis (recurrence of narrowing of a blood vessel) events at 1 year compared to balloon-expandable (BE) stents. Restenosis incidents in self-expanding (SE) stent procedure is 6.1 percent compared to 14.9 percent in balloon-expandable (BE) stent procedure. The study results also show no difference in walking impairment, amputation rate, hemodynamic (dynamics of blood flow) success, complications before, during or after the stent procedure or all-cause death.

Iliac artery atherosclerosis plaque blockage treated with self-expanding SE stent than balloon-expandable BE.

Lead investigator of the study was Dr. Hans Krankenberg, Angiology, a specialist in internal medicine, cardiology, Department of Angiology, Asklepios Klinikum Harburg, Hamburg, Germany. The study findings were published online August 20, 2017, in the Journal of the American College of Cardiology. Title of the article was "Self-Expanding Versus Balloon-Expandable Stents for Iliac Artery Occlusive Disease: The Randomized ICE Trial."

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Repairing and self-healing of damaged hearts after a heart attack and heart failure by preventing Singheart RNA molecule

Researchers at the National University Health System (NUHS) and the Genome Institute of Singapore (GIS), Singapore have discovered a ribonucleic acid (RNA) molecule, named as Singheart molecule, which prevents self-healing and repairing of the damaged heart cells in heart failure and heart attack patients. Researchers say Singheart molecules are a single-stranded equivalent of DNA and having the power to manage other genes. They prevent the heart from self-healing by preventing cell processes such as division, regeneration etc.

Their studies show heart cells of heart disease patients contains large quantities of Singheart molecules. They think that older patients heart cells may also contain large quantities of Singheart molecule. Researchers found regeneration, self-repairing and self-healing of heart cells when they neutralized and blocked these Singheart molecules in their experiments with mice models. The experiments with heart attack induced adult mice model shows complete healing of heart within a month after injecting complementary molecules.

Skin cells have the ability to heal themselves. But heart cells are deprived of self-healing process and suffers permanent scar due to the presence of Singheart molecule. Researchers say there will be no effects of a heart attack if the heart cells heal like the skin cells.

Self-healing repairing heart attack heart failure damaged heart by blocking Singheart RNA molecule.

This was the first study showing an association between RNA and heart failure. Researchers say they are going to conduct human trials within next five years with their study findings. Lead author and the principal investigator of the study was Associate Professor Roger Foo. The first author of the study was Dr. Kelvin See. The study findings were published on August 9, 2017, in the Nature Communications. Title of the article was "Single cardiomyocyte nuclear transcriptomes reveal a lincRNA-regulated de-differentiation and cell cycle stress-response in vivo."

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