 | Diabetes, Cardiovascular and Heart Diseases Article 272 Published on November 30, 2017 |
Life-saving CORolla heart-implant device for the treatment of diastolic heart cardiac failure
The survival chances of a heart failure patient are poor. Studies show more than 40 percent of the heart failure patients die within five years. About 50 percent of them die due to diastolic heart failure. Risks for diastolic heart failure increases with age. Diastolic heart failure events are common among those women who are with high blood sugar or glucose levels (or type 2 diabetes T2D), hypertension (or high blood pressure) and obesity (or high body mass index BMI). There are no effective medications, drugs or treatments for diastolic heart failure.
CorAssist Cardiovascular Ltd, a Haifa, Israel based start-up company give a new hope for diastolic heart failure patients. The company has developed an innovative CORolla cardiac implant procedure. The CORolla is an elastic device to improve cardiac diastolic function. The procedure involved in the CORolla implant device is minimally invasive. This device will be implanted into the left ventricle of the heart while the heart is beating. The device improves the diastolic function of the heart by applying direct internal expansion forces on the septum and on the walls of the left ventricle.
This technology was developed by Dr. Yair Feld, a cardiologist at the Rambam Health Care, Haifa, Israel. Dr. Shay Dubi and Dr. Yotam Reisner were also associated with the CORolla implant device development. The first procedure was performed by a team of professionals led by Professor Gil Bolotin, director of the Department of Cardiac Surgery.
Robert MacLachlan, a Canadian aged 72 years (a diastolic heart failure patient) was the first patient to undergo experimental life-saving CORolla heart-implant procedure in the Rambam hospital on August 28, 2017. Researchers got authorization for up to 10 clinical trials of CORolla implant from the Health Ministry.
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Septum : A wall that divides left and right sides of the heart.
Diastolic heart failure : When blood did not fill into the lower left ventricle of the heart during diastolic (blood filling) phase, the amount of blood pumped out of the heart to body organs is less than normal. This condition is called diastolic heart failure.
Type 2 diabetes (T2D) increases the risk of the development of coronary heart disease (CHD), a major cause of premature death. Earlier studies could not uncover the reasons behind the development of coronary heart disease (CHD) due to type 2 diabetes (T2D). A current study shows similar genes causes the development of both type 2 diabetes (T2D) and heart diseases and they can be prevented with a single drug or pill.
Scientists have found seven mutations (changes in the gene structure) after analyzing complete DNA in more than 250,000 individuals belonging to East Asian, South Asian or European descent. These similar gene mutations have increased the risk for type 2 diabetes (T2D) and heart diseases. Researchers have found that the incidents of 65 percent of heart failures and 48 percent of heart attacks among type 2 diabetes (T2D) patients are due to these gene associations.
Scientists also found that the mutation of the ApoE gene lowers risk of the development of coronary heart disease (CHD) but increases the risk for the development of type 2 diabetes (T2D). Researchers say these phenomena have explained the reason for the reduction in "BAD" or LDL cholesterol levels in the bloodstream, but an increase in the risk for the development of type 2 diabetes (T2D) with statin drug treatment.
Scientists say risks for coronary heart disease and type 2 diabetes (T2D) could be lowered by treating both the conditions with a single drug or pill by identifying gene variants associated with both the diseases. There are possibilities to develop type 2 diabetes (T2D) drugs with either neutral or beneficial effects on coronary heart disease (CHD).
Co-senior authors of the study are Dr. Danish Saleheen, MBBS, PhD, an assistant professor of Epidemiology, Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania and Dr. Benjamin F. Voight, PhD, an associate professor of Genetics, Perelman School of Medicine, University of Pennsylvania. The study findings were published on September 4, 2017, in the Nature Genetics. Title of the article was "Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease."
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ApoE : ApoE gene helps in producing apolipoprotein E protein. This protein combines with lipid fats to form lipoprotein molecules. These molecules are responsible for packaging of cholesterol and carry them in the bloodstream.
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