Diabetes, Cardiovascular, and Heart Diseases  Article 293     Published on January 20, 2018

Psoriasis is a common dermatological or inflammatory skin disease and a lifelong autoimmune disease. About two to four percent of the adults were affected by psoriasis. An earlier study shows an association between psoriasis and the heart attack (the medical name is myocardial infarction), cardiovascular diseases, stroke, mortality (death), type 2 diabetes (T2D) and chronic inflammation.

A study at the Perelman School of Medicine, University of Pennsylvania, Philadelphia, the United States shows the risk of type 2 diabetes (T2D) in the people with psoriasis and the risk of type 2 diabetes (T2D) increases with the severity of psoriasis. This is the first study exploring the effects on type 2 diabetes (T2D) with the severity of psoriasis. This study has found a biological connection between type 2 diabetes (T2D) and psoriasis. The study also found that psoriasis promotes insulin resistance.

A study on 8,124 people with psoriasis and 76,599 people without psoriasis, has collected the body surface area (BSA) of the psoriasis patients. The body surface area (BSA) shows the severity of psoriasis. They have done a follow-up study for four years.

The follow-up study shows a new type 2 diabetes development in 280 (3.44 percent) people in the psoriasis group and 1,867 (2.44 percent) people in without psoriasis group. Researchers accounted for risk factors to type 2 diabetes (T2D) such as the age of an individual, sex, obesity ( body mass index. BMI ). The study has found the following.

• About 21 percent of the increased risk of type 2 diabetes (T2D) in the people affected with psoriasis with a body surface area (BSA) up to two percent compared to people without psoriasis.

• About 64 percent of the higher risk of type 2 diabetes (T2D) in the patients affected with psoriasis with the body surface area (BSA) of ten percent or more compared to people without psoriasis.

• For every ten percent increase in the body surface area (BSA), the risk of type 2 diabetes (T2D) increases by 20 percent in psoriasis patients compared to people without psoriasis.

Researchers say that the healthcare professionals should provide a special attention for the prevention of type 2 diabetes (T2D) in the patients with psoriasis with the body surface area (BSA) more than ten, as they are at a higher risk to type 2 diabetes.

The lead author of the study was Joel M. Gelfand, a professor of dermatology and epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, the United States. The study was published November 8, 2017, in the Journal of the American Academy of Dermatology. Title of the article was "Psoriasis and the Risk of Diabetes: A Prospective Population-Based Cohort Study."
DOI : doi.org/10.1016/j.jaad.2017.10.050

       
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