Patients Of Type 2 Diabetes With Chronic Kidney Disease May Survive Longer With Metformin
An observational and the national cohort study shows 36 percent of the lower risk of death (mortality) in the patients of type 2 diabetes with a chronic kidney disease (CKD) by starting the metformin treatment compared with patients starting with the sulfonylurea drug treatment. The study also shows that patients of type 2 diabetes with a chronic kidney disease (also called chronic renal failure. CRF) may survive longer with metformin.
An observational study was done between 2004 and 2009 on 175,296 veterans who received at least one-year treatment from the Veterans Health Administration (VHA), a part of the United States Department of Veterans Affairs (VA). After receiving the treatment from the VHA, all of them were under a monotherapy (usage of a single drug) for the treatment of type 2 diabetes with either sulfonylurea or metformin. The study shows.
The following table shows the risk reduction among patients with type 2 diabetes with a chronic kidney disease (CKD) who started with metformin compared with those patients who started with the sulfonylureas.
The FDA guidance advises the initiation of metformin for the patients of type 2 diabetes with an estimated glomerular filtration rate (eGFR) between 45 and 59
The lead author of the study was James S. Floyd, MD, the University of Washington, Seattle, the United States. The study was published on November 27, 2017, in the Journal of General Internal Medicine. Title of the article was "Mortality Associated with Metformin Versus Sulfonylurea Initiation: A Cohort Study of Veterans with Diabetes and Chronic Kidney Disease."
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Published by Jammi Vasista, Chennai, India.