Type 2 diabetes patients with chronic kidney diseases can survive longer with metformin
An observational and national cohort study shows a 36 percent of the lower risk of death (mortality) in type 2 diabetes patients with chronic kidney diseases (CKD) by starting the metformin treatment compared with patients starting with the sulfonylurea drug treatment. The study shows type 2 diabetes patients with chronic kidney diseases (also called chronic renal failure. CRF) may survive longer with metformin.
An observational study was done between 2004 and 2009 on 175,296 veterans who received at least one-year treatment from the Veterans Health Administration (VHA), a part of the United States Department of Veterans Affairs (VA). After receiving the treatment from the VHA, all of them were under a monotherapy (usage of a single drug) for the treatment of type 2 diabetes with either sulfonylurea or metformin. The study shows.
The FDA guidance advises the initiation of metformin for the type 2 diabetes patients with an estimated glomerular filtration rate (eGFR) between 45 and 59
Lead author of the study was James S. Floyd, MD, the University of Washington, Seattle, the United States. The study was published November 27, 2017, in the Journal of General Internal Medicine. Title of the article was "Mortality Associated with Metformin Versus Sulfonylurea Initiation: A Cohort Study of Veterans with Diabetes and Chronic Kidney Disease."
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Published by Jammi Vasista, Chennai, India.