Diabetes, Heart, and Cardiovascular Diseases News Chronicle.  Diabetes, Cardiovascular, and Heart Diseases
 Article 300
    Published on February 2, 2018


Patients Of Type 2 Diabetes With Chronic Kidney Disease May Survive Longer With Metformin


An observational and the national cohort study shows 36 percent of the lower risk of death (mortality) in the patients of type 2 diabetes with a chronic kidney disease (CKD) by starting the metformin treatment compared with patients starting with the sulfonylurea drug treatment. The study also shows that patients of type 2 diabetes with a chronic kidney disease (also called chronic renal failure. CRF) may survive longer with metformin.

Ads A simple way to reverse type 2 diabetes
See More Ads For "Reversal Of Diabetes"

Metformin can cause a lower risk of death (mortality) in a patient of type 2 diabetes with a chronic kidney disease.

An observational study was done between 2004 and 2009 on 175,296 veterans who received at least one-year treatment from the Veterans Health Administration (VHA), a part of the United States Department of Veterans Affairs (VA). After receiving the treatment from the VHA, all of them were under a monotherapy (usage of a single drug) for the treatment of type 2 diabetes with either sulfonylurea or metformin. The study shows.

  • A death of 5,121 individuals.
  • Those individuals under the treatment with the metformin (monotherapy) had 36 percent of the lower risk of death (mortality) compared with those individuals under the treatment with the sulfonylurea (monotherapy).
  • The amount of risk reduction varies with the estimated glomerular filtration rate (eGFR).
  • The largest absolute risk reduction was observed in the patients with a moderate to severe reduction in eGFR.
  • The researchers did not find the risk of serious acidosis in patients with chronic kidney diseases (CKD) with an eGFR between 30 and 45 mL/min/1.73m2.

Ads World's first & only carb cycling diet. Lose 7-11 pounds in the first 7 days.
See More Ads For "Body Weight Loss"

The following table shows the risk reduction among patients with type 2 diabetes with a chronic kidney disease (CKD) who started with metformin compared with those patients who started with the sulfonylureas.

Ads 21 Day rapid weight loss program
See More Ads For "Body Weight Loss"

eGFR (mL/min/1.73m2) Risk reduction Fewer deaths per
1000 person-years
Equal to or more than 90 41 percent 3.0
Between 60 and 89   4.3
Between 45 and 59 20 percent 3.4
Between 30 and 44 Greatest risk reduction 12.1

The FDA guidance advises the initiation of metformin for the patients of type 2 diabetes with an estimated glomerular filtration rate (eGFR) between 45 and 59 mL/min/1.73m2. The FDA also suggests that patients of type 2 diabetes with a severe kidney disease would be benefited with the initiation of metformin. This study supports the current FDA guidance.

The lead author of the study was James S. Floyd, MD, the University of Washington, Seattle, the United States. The study was published on November 27, 2017, in the Journal of General Internal Medicine. Title of the article was "Mortality Associated with Metformin Versus Sulfonylurea Initiation: A Cohort Study of Veterans with Diabetes and Chronic Kidney Disease."
DOI: doi.org/10.1136/bmjopen-2012-001076

Ads Say "GOODBYE" to your diabetes
See More Ads For "Reversal Of Diabetes"

If you like this article, please share it with a friend! Article address is (copy and paste the code below) :

Articles similar to this topic

Ads A "METABOLISM MINERAL" trick to losing weight
See More Ads For "Body Weight Loss"

1. Improved Mortality Among Older Type 2 Diabetes Individuals With Metformin
2. Kidney failure, amputations, blindness, heart attack and stroke complications by delaying insulin therapy among patients with type 2 diabetes
3. Blood Pressure Damages Kidney
4. Diabetes Link To Chronic Kidney Disease (CKD)
5. Chronic Kidney Disease, Heart Disease & Diabetes Prevention Drugs From Forxiga Drug Maker AstraZeneca
6. Transplanting Diabetic Kidneys Better Than Remaining On Waitlist
7. Canagliflozin SGLT2 anti-diabetes drug reduces kidney and heart disease risk

Ads How to reverse type 2 diabetes with a scientifically-proven method!
See More Ads For "Reversal Of Diabetes"

8. About End Stage Renal Disease (ESRD)
9. Curing Hepatitis C Reduces The Risk Of Kidney Failure
10. Role Of Metformin Diabetes Drug
11. Metformin improves health outcomes in HER2 and breast cancer patients with diabetes
12. A big contributor to the heart-related deaths is kidney or renal disease
13. Renal Denervation To Improve Insulin Sensitivity
14. Obesity Increases Type 2 Diabetes Or Post Donation Diabetes Mellitus (PDDM) Risk Among Living Kidney Donors (LKD)
15. Risks With Chronic Kidney Disease CKD
16. Updated Guidelines Reaffirms Faith In Metformin

Ads A simple way to lose belly fat and unwanted body fat
See More Ads For "Lowering Body Fat"




Sitemap 1   Sitemap 2   Sitemap 3   Sitemap 4


The Diabetes News Chronicle does not provide medical advice, diagnosis or treatment. Information in Diabetes News Chronicle is to support and not to replace medical advice given by the surgeon or physician or doctor. The published article is not medical advice by the OWNER of the "Diabetes News Chronicle" website or by the AUTHOR of the article.

Published by Jammi Vasista, Chennai, India.
Email Jammi[no-space]Vasista1991[at]gmail[dot]com
Phone 91-944-578-3182.
Address Diabetes News Chronicle, No 40, Kaveri Street, Rajaji Nagar, Villivakkam, Chennai, India. Pin : 600049.