Diabetes, Heart, and Cardiovascular Diseases News Chronicle.
Article 229   Published on August 19, 2017

The Risk Of Type 2 Diabetes, High Blood Pressure And Cardiovascular Diseases With Phthalates

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A study by the Australian researchers at the South Australian Health and Medical Research Institute (SAHMRI) and the University of Adelaide has linked the development of chronic diseases such as high blood sugar (glucose) levels (type 2 diabetes), cardiovascular disease and hypertension (high blood pressure. BP) in men with phthalates.


The risk of type 2 diabetes, hypertension, cardiovascular diseases with phthalates in plastics.

Phthalates are a toxic chemical used for making food packaging and plastics and they are very dangerous. The plastic products manufacturers use phthalates to improve the flexibility of the plastics.



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The researchers have conducted a study on 1,500 men, aged 35 years or more. The study shows the presence of phthalates in the urine sample of 99.6 of the participants. The following are the possible reason for the presence of high level of phthalates.

  • Western diet.
  • The consumption of fruit and vegetables is less than the standard.

The study has found higher sugar (glucose) levels, hypertension (high blood pressure. BP) and cardiovascular diseases in those participants who are with higher total phthalate level.

The study also found that the risk of chronic health conditions and diseases with the presence of phthalates is independent of other health risk factors such as lifestyle, obesity, alcohol consumption and smoking.


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But the researchers could not provide the reason for the development of chronic diseases with the presence of phthalates. Even though the researchers have found the evidence to the development of diseases with the presence of phthalates in men, they believe similar results among women.

The senior author of the study was Zumin Shi, an associate professor, Adelaide Medical School, the University of Adelaide, Australia and Freemasons Foundation Centre for Men's Health. The study was published in July 2017 in the Journal of Environmental Research. Title of the article was "The association between total phthalate concentration and non-communicable diseases and chronic inflammation in South Australian urban dwelling men."
DOI: doi.org/10.1016/j.envres.2017.06.021



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Urocortin 2 (Ucn2) Gene Transfer Can Improve Insulin Sensitivity And Can Lower Blood Sugar (Glucose) Levels (HbA1c)

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A study on mice models shows an increase in the insulin sensitivity (cause an improvement in blood sugar level or HbA1c) with Urocortin 2 (Ucn2) gene transfer. Urocortin 2 (Ucn2) gene transfer can activate a receptor in the insulin resistant cells.


Urocortin 2 (Ucn2) gene transfer can improve insulin sensitivity in blood sugar glucose levels (HbA1c).

The mice models in the study are lacking with Urocortin 2 (Ucn2) gene. These mice models are fed with an unhealthy diet. The study shows lower fat accumulation, increased lean muscle tissue and increased insulin sensitivity in these mice models.


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Other benefits with Urocortin 2 (Ucn2) gene transfer are weight loss, reduction in liver fat, improvement in the blood sugar level (improvements in HbA1c) and improved heart function.

This therapy was designed by Dr. Kirk H Hammond, MD, Professor of Medicine, the University of California (UCSD) and also the co-founder of Renova Therapeutics, a biotechnology company. The Renova Therapeutics is going to deliver this gene therapy to patients.


Urocortin 3 (Ucn3) gene transfer was invented by Dr. Kirk H Hammond. The therapy was intended to improve the function of the heart in patients of heart failure. This therapy is similar to the Urocortin 2 (Ucn2) gene therapy.


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Now the researchers are planning to conduct a clinical trial of Urocortin 2 (Ucn2) gene therapy on patients with type 2 diabetes (T2D).

The study was published in the National Center for Biotechnology Information and also presented at the American Heart Association Scientific Sessions. Title of the article was "One-time injection of AAV8 encoding urocortin 2 provides long-term resolution of insulin resistance."
DOI: dx.doi.org/10.1172%2Fjci.insight.88322



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